Advanced plasmonic biosensors: towards the next-generation biomolecular interaction analysis

Sponsor: Czech Science Foundation

Principal investigator: Prof. Jiří Homola, Ph.D., DSc.

Project partners: Institute of Macromolecular Chemistry, Prague; Institute of Hematology and Blood Transfusion, Prague

To: 2022-06-30

Life is associated with myriad of interactions that occur among a large variety of biomolecules. Hence, the understanding of biomolecular interactions and their roles in diseases represents a research goal of paramount importance. This project aims to develop a new plasmonic biosensor-based technology that will enable investigation of biomolecular interactions in complex real-world biological environments, which will advance the field of biomolecular interaction analysis beyond the current state of the art. This multidisciplinary project encompasses research efforts in multiple areas, including plasmonic (nano)structure-based biosensors, mass transport in microfluidic systems, immobilization of biomolecules, and methodologies for investigation of biomolecular interactions. The resulting biosensor technology will provide new insights into interaction of biomolecules involved in onco-hematological diseases, such as myelodysplastic syndrome and other frequently occurring hematological malignancies.